活动时间 | Time

北京时间2021年12月21日（周二） 20:00-21:00

2021 December 21st Tuesday 20:00-21:00 (Beijing Time)

参与方式 | Location

Zoom网络研讨会: 843 6931 3262

Bilibili直播：http://live.bilibili.com/22741871

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Webinar ID: 843 6931 3262

Bilibili Live: http://live.bilibili.com/22741871

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主讲人 | Speaker

Alexander Meissner

主讲人简介 | Speaker Biography

Dr. Alexander Meissner studied Medical Biotechnology at the Technical University Berlin before starting his PhD studies with Rudolf Jaenisch at the Whitehead Institute/MIT in 2002. He completed his PhD in 2006 and spent the next year and a half working with Rudolf Jaenisch and Eric Lander before starting his own lab as an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University and as an associate member of the Broad Institute in 2008. He was promoted to associate professor in 2012 and full professor with tenure in 2015. In 2016 he has been appointed as Director and Head of the Department of Genome regulation at the Max Planck Institute for Molecular Genetics in secondary employment and changed it to his principal employment in 2017. Dr. Meissner is interested in epigenetic regulation. Together with his team of experimental and computational biologists, he studies the parameters that cause multipotent stem cells to develop into highly specialized cells making up all tissues of an organism.

Alexander Meissner博士本科在柏林工业大学学习医学生物技术，2002年开始在麻省理工学院怀特黑德研究所跟随Rudolf Jaenisch进行博士研究。他于2006 年取得博士学位后，继续跟随Rudolf Jaenisch和Eric Lander进行博士后工作。2008年他在哈佛大学干细胞与再生生物学系担任助理教授并创办自己的实验室，并成为博德研究所的准成员。他于2012年晋升为副教授，2015 年成为终身正教授。他在2016年被任命为马克斯普朗克分子遗传学研究所基因调控 系的主任和负责人，并于2017年将此转为主要工作。Meissner博士的研究兴趣是表观遗传调控。他与他团队中的实验和计算生物学家一起致力于研究导致多能干细胞发育成构成生物体所有组织的高度特化细胞的影响因素。

报告标题 | Title

Epigenetic Mechanisms in Development and Disease

主讲人近年发表论文| Recent Publications

1) Blanco, M. A.; Sykes, D. B.; Gu, L.; Wu, M.; Petroni, R.; Karnik, R.; Wawer, M.; Rico, J.; Li, H.; Jacobus, W. D. et al.: Chromatin-state barriers enforce an irreversible mammalian cell fate decision. Cell Reports 37 (6), 109967 (2021)

2) Andergassen, D.; Smith, Z. D.; Kretzmer, H.; Rinn, J. L.; Meissner, A.: Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages. Developmental Cell 56 (21), e4, pp. 2995 - 3005 (2021)

3) Hetzel, S.; Gießelmann, P.; Reinert, K.; Meissner, A.; Kretzmer, H.: RLM: Fast and simplified extraction of Read-Level Methylation metrics from bisulfite sequencing data. Bioinformatics 37 (21), pp. 3934 - 3935 (2021)

4) Gu, H.; Raman, A. T.; Wang, X.; Gaiti, F.; Chaligne, R.; Mohammad, A. W.; Arczewska, A. A.; Smith, Z. D.; Landau, D. A.; Aryee, M. J. et al.: Smart-RRBS for single-cell methylome and transcriptome analysis. Nature Protocols 16, pp. 4004 - 4030 (2021)

5) Yagi, M.; Ji, F.; Charlton, J.; Cristea, S.; Messemer, K.; Horwitz, N.; Di Stefano, B.; Tsopoulidis, N.; Hoetker, M. S.; Huebner, A. J. et al.: Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells. Genes and Development 35 (17-18), pp. 1209 - 1228 (2021)

6) Huang, Y.-H.; Chen, C.-W.; Sundaramurthy, V.; Słabicki, M.; Hao, D.; Watson, C. J.; Tovy, A.; Reyes, J. M.; Dakhova, O.; Crovetti, B. R. et al.: Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor. Cancer Discovery, CD-21-0560 (2021)

7) Wu, H.-J.; Landshammer, A.; Stamenova, E. K.; Bolondi, A.; Kretzmer, H.; Meissner, A.; Michor, F.: Topological isolation of developmental regulators in mammalian genomes. Nature Communications 12, 4897 (2021)

8) Bulut-Karslioglu, A.; Jin, H.; Kim, Y.-K.; Cho, B.; Guzman-Ayala, M.; Williamson, A. J. K.; Hejna, M.; Stötzel, M.; Whetton, A. D.; Song, J. S. et al.: Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells. Nature Communications 12, 4859 (2021)

9) Haggerty, C.; Kretzmer, H.; Riemenschneider, C.; Sampath Kumar, A.; Mattei, A. L.; Bailly, N.; Gottfreund, J.; Giesselmann, P.; Weigert, R.; Brändl, B. et al.: Dnmt1 has de novo activity targeted to transposable elements. Nature Structural and Molecular Biology 2021 (2021)

10) Bolondi, A.; Haut, L.; Gassaloglu, S. I.; Burton, P.; Kretzmer, H.; Buschow, R.; Meissner, A.; Herrmann, B. G.; Veenvliet, J. V.: Generation of Mouse Pluripotent Stem Cell-derived Trunk-like Structures: An in vitro Model of Post-implantation Embryogenesis. Bio-protocol 11 (11), e4042 (2021)

11) Rossmann, M. P.; Hoi, K.; Chan, V.; Abraham, B. J.; Yang, S.; Mullahoo, J.; Papanastasiou, M.; Wang, Y.; Elia, I.; Perlin, J. R. et al.: Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science 372 (6543), pp. 716 - 721 (2021)

12) Pan, H.; Renaud, L.; Chaligne, R.; Bloehdorn, J.; Tausch, E.; Mertens, D.; Fink, A. M.; Fischer, K.; Zhang, C.; Betel, D. et al.: Discovery of candidate DNA methylation cancer driver genes. Cancer Discovery 2021, 20-1334 (2021)

13) Hübschmann, D.; Kleinheinz, K.; Wagener, R.; Bernhart, S. H.; López, C.; Toprak, U. H.; Sungalee, S.; Ishaque, N.; Kretzmer, H.; Kreuz, M. et al.: Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia: the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K. 2021 (2021)

往期回顾 | Past Webinars

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