中国细胞生物学学会
2022年全国学术大会·厦门

姚雪彪 教授，中国科技大学
YAO Xuebiao, University of Science and Technology of China

毕国强 教授，中国科学院深圳先进技术研究院
BI Guoqiang, Shenzhen Institutes of Advanced Technology，CAS

-

Global Cell Biology and Synergism：Cell Plasticity and Fine Cyto-architecture Visualization of specific molecules and their interactions in real space and time is essential to delineate how cellular plasticity and dynamics are achieved as perturbation of cellular plasticity and dynamics is detrimental to health. Molecular and cell biologists have traditionally delineated cellular complexity using a reductionist approach by studying molecular components individually. Emerging correlative light and electron microscopic analyses provide a unique approach to elucidate cellular architecture and machinery dynamics at nanometer scale at millisecond resolution. This session provides a unique forum to feature speakers from ASCB│CSCB│EMBO to address how fine cyto-architectures orchestrate cell plasticity in diversified systems.

刘明耀 教授，华东师范大学 
LIU Mingyao, East China Normal University  

王平 教授，同济大学 
WANG Ping，Tongji University 

细胞信号转导异常与肿瘤的发生和发展密切相关，肿瘤细胞的命运又受细胞信号转导和肿瘤微环境的严格调控。利用新技术和新模型解析肿瘤生长、转移、细胞命运决定以及微环境调节中的信号机制将会极大地推动肿瘤精准医疗的发展。本分会场将邀请肿瘤基础研究以及临床研究的专家学者交流肿瘤细胞调控和肿瘤治疗领域的新进展和新成果。

Aberrant cell signaling transduction is closely related to tumor initiation and progression. Tumor cell fate determination is in turn tightly controlled by cell signaling transduction and tumor microenvironment. Exploration and dissection of signaling pathways involved in tumor growth, metastasis, cell fate determination or microenvironment regulation using new technologies and new models will largely promote the development of tumor precision medicine. In this session, we will invite experts (both basic and clinical) to share their achievements in the field of tumor cell regulation and targeted therapy.

贾大 教授，四川大学 
JIA Da, Sichuan University 

宋质银 教授，武汉大学 
SONG Zhiyin, Wuhan University 

细胞器是真核细胞执行生命活动的功能区域。不同的细胞器既精细分工，又相互协调，从而执行多种生物学过程。本会场旨在召集近两年在细胞器研究领域做出突出成绩的知名学者及青年PI分享最新研究成果，包括新型细胞器、细胞器互作、线粒体应激、自噬、膜融合及分裂、神经递质释放、囊泡运输、新技术等方面。

An organelle is a specialized subunit, in a cell, that has a specific function. Although each organelle has distinctive functions, they often cooperate to function in diverse biological processes. In this session, we aim to recruit established investigators and rising stars to discuss recent breakthroughs in the field including, but not limited to, new organelles, organelle- organelle interaction, mitochondria stress, autophagy, membrane fusion and fission, membrane trafficking, and new techniques in studying organelles.

杨晓 研究员，国家蛋白质科学中心（北京） YANG Xiao, National Center for Protein Sciences (Beijing)

周斌 研究员，中国科学院分子细胞科学卓越创新中心 
ZHOU Bin, Center for Excellence in Molecular Cell Sciences, CAS 

器官发育与组织稳态维持是个非常复杂、受到精细调控的过程，一旦稳态被打破，就会在细胞和分子层面发生多维度的病理生理改变，引起相关疾病。本会场聚焦该领域前沿进展，利用新技术解析正常和疾病过程中多组织器官病理生理的细胞和分子调控机理，探讨器官发育、组织稳态和疾病发生机制，为疾病临床治疗提供科学依据与理论支持。

Organ development and tissue homeostasis are tightly orchestrated by a complex of cellular and molecular programs. Aberrant cellular and molecular events may lead to multiple pathological processes, which are associated with diseases. This session would focus on the cellular and molecular mechanism underlying the pathophysiological process in normal and disease conditions. Mechanistic understanding of these biological process would provide new insights on organ development, tissue homeostasis, and diseases.

徐楠杰 研究员，上海交通大学医学院 
XU Nanjie, Shanghai Jiao Tong University School of Medicine 

郭伟翔 研究员 ，中国科学院遗传与发育生物学研究所 
GUO Weixiang, Institute of Genetics and Developmental Biology, CAS 

神经发育过程受到许多内在和外在因子的精细调控；神经系统的结构和功能蕴含复杂的细胞和分子机制。本分会场旨在交流神经系统发育和功能领域的细胞生物学新技术和新成果，为在细胞和分子水平更深入的理解神经发育和功能调节机理提供理论指导。

The neural development is precisely regulated by extrinsic and intrinsic factors; the structure and function of the nervous system involve sophisticated cellular and molecular mechanisms. The purpose of this topic is to exchange new technologies and achievements in cell biology in the field of development and function of the nerve system, and to provide theoretical guidance for a deeper understanding of the mechanisms of neural developmental and functional regulation at the cellular and molecular levels.

张勇 教授,苏州大学 
ZHANG Yong, Soochow University 

秦曦明 副教授，安徽大学 
QIN Ximing, Anhui University 

生物钟是生物体内的计时系统，能够调控生物的生理与行为，从而帮助生物体更好地适应昼夜交替的环境变化。本会场将围绕生物钟的主要组成，讨论授时因子、生物钟机制，以及生物钟对生理和健康的调控。

Biological clock is the timekeeping mechanism that synchronizes selfsustained rhythms in physiology and behavior to the cyclic changes of environmental cues. 
This session will discuss the biological clock and external zeitgebers, pacemaker mechanism, as well as the significance of biological clock for physiology and health.

余鹰 教授, 天津医科大学 
YU Ying, Tianjin Medical University 

孙宁 教授/研究员, 复旦大学 
SUN Ning, Fudan University 

心血管疾病依然是全球流行且致死率最高的疾病。代谢及其调控机制在心血管系统的生理与病理过程中扮演了非常重要的作用，是近年来心血管疾病研究的重点之一。代谢及其调控如何在心血管疾病中发挥作用，发掘可干预的新型分子靶标，推动临床转化，是代谢与心血管领域的重要科学问题。本分会场将聚焦于"代谢调控与心血管疾病"这一主题，探讨代谢调控与心血管疾病发生发展的密切关系与分子机制，挖掘代谢调控在心血管相关疾病中的潜在干预靶标，推动临床转化，为实现心血管健康提供科学依据和理论支持。

Cardiovascular diseases (CVDs) remain to be pandemic over the world and are the main global cause of death. Metabolic disorders are implicated in various CVDs such as heart failure and atherosclerosis. The underlying molecular mechanisms for metabolic disorders in CVDs, and the related potential therapeutic targets and translational applications in clinics need to be further explored. In this section- “Metabolic regulation and CVDs”, novel research findings regarding mechanistic insight in metabolic CVDs, and metabolic interventions for CVD therapy will be discussed.

周大旺 教授，厦门大学生命科学学院 
ZHOU Dawang, Xiamen University 

赵斌 教授，浙江大学生命科学研究院 
ZHAO Bin, Zhejiang University 

Hippo通路作为近年来新发现的信号通路，在细胞命运决定、干细胞自我更新、组织器官大小调控与再生、肿瘤发生发展和其他疾病等生命过程中起着关键作用，已经成为细胞、发育、癌症等领域的研究焦点之一。中国在Hippo通路研究上做出了重要贡献，具有较强的国际影响力，新成果不断涌现。本分会场将探讨Hippo信号通路调控与功能相关的研究体系和前沿进展。

The Hippo pathway plays key roles in cell proliferation and cell death, self-renewal and differentiation, organ size control and regeneration. Furthermore, its deregulation leads to cancer and other diseases. In recent years, it has attracted broad attention in the fields of cell biology, developmental biology, and cancer biology. Chinese scientists have made critical contributions to the establishment of the Hippo pathway, and continuously impact the field by frontier discoveries. In this session we will discuss recent advances in regulations and functions of the Hippo pathway.

李国红 研究员，中科院生物物理所
 LI Guohong, Institute of Biophysics, CAS 

沈晓骅 教授，清华大学医学院 
SHEN Xiaohua, Tsinghua University School of Medicine 

转录、RNA代谢和染色质高级构象是紧密相连的，这些功能的协同对细胞核功能以及发育及干细胞分化起着重要作用。本分会场将主要探讨细胞核的稳态，包括RNA和染色质调控，是如何影响基因表达和细胞命运决定，这些机制的异常如何导致人类疾病的发生。

Transcription, RNA processing and genome organization are intrinsically coupled and play important roles in the operation and homeostasis of the nucleus during development and differentiation. This session will focus on the cutting-edge advances and crosstalk between RNA processing, transcription, and the higher-order chromatin structure in the regulation of stem cell fate, and how their dysregulation leads to human disease.

何志颖 教授，同济大学附属东方医院 
HE Zhiying, Shanghai East Hospital of Tongji University 

黄鹏羽 教授，中国医学科学院生物医学工程研究所 
HUANG Pengyu, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences 

肝脏承担着代谢、解毒、储存糖原、合成分泌性蛋白等重要生理功能。病毒感染、药物损伤、自身免疫性疾病、代谢失调等多种因素都有可能造成肝脏损伤，长期病因不能去除导致病人发展为肝衰竭或肝癌。通过基因治疗、细胞治疗、组织工程等前沿技术手段，实现肝脏的再生修复，是肝脏疾病治疗的重要发展方向。本分会场将围绕肝脏再生的调控机制、肝脏再生医学技术及其临床转化，从基础到临床转化方面探讨和交流肝脏再生研究的前沿进展。

The liver plays a central role in the metabolism of nutrients, detoxification, storage of glycogen, and syntheses of secretory proteins. The liver injury could be induced by the virus infection, drugs, autoimmune disease, metabolic disorder, etc. Continuous exposure to the pathogenic factors could result in liver failure and liver cancer. The emerging regenerative medicine strategies, such as gene therapy, cell therapy, and tissue engineering, provide cutting-edge directions for treating liver diseases. This session will focus on the regulatory mechanisms, medical technologies, clinical and translational medicines of liver regeneration and discuss the advanced development of liver regeneration research from basic to clinical research.

李劲松 院士、研究员，中科院分子细胞科学卓越创新中心（生化与细胞所） 
LI Jinsong, Center for Excellence in Molecular Cell Science, CAS 

万国强 副教授，南京大学模式动物研究所 
WAN Guoqiang, Model Animal Research Center, Nanjing University 

新型细胞模型，如单倍体干细胞和类器官模型为生命科学研究带来了前所未有的机遇。携带精子遗传物质的孤雄单倍体干细胞不仅为高通量正反向遗传筛选提供了新的工具，也可作为载体将基因编辑器通过“受精”带到胚胎中，为研究胚胎发育和细胞命运决定提供新的遗传学工具。类器官是利用干细胞直接诱导生成的三维组织模型微器官，在人类基因功能、疾病建模、生物样本建库、病理机制、药物筛选、再生医学等基础和临床研究具有无可比拟的优势。本会场将聚焦于单倍体干细胞和类器官模型的开发与应用，以探究遗传，发育和再生等生命过程的分子细胞生物学机制。

Haploid embryonic stem cells and stem cell-derived organoids provide unprecedented cellular models for research in life sciences. Haploid embryonic stem cells not only allow high throughput genetic screening in live mice, but also facilitate robust genetic modifications by “pseudo-fertilization” for studies in embryonic development and cell fate determination. Organoids are derived from stem cells and cultured as 3D mini-organs. Over the years, organoid technology has greatly promoted research into human genome functions, biobanking, disease modeling and pathological studies, drug screening and regenerative medicine. This forum will focus on the development and applications of these new cell models in unraveling the molecular and cellular mechanisms in genetic, developmental and regenerative biology.

韩俊海 教授 东南大学 
HAN Junhai, Southeast University 

仇子龙 研究员，中国科学院脑科学与智能技术卓越创新中心  
QIU Zilong, Center for Excellence in Brain Science and Intelligent Technology, CAS  

神经信号传导是神经活动的基本过程，该过程的异常会导致众多疾病。本分会场将邀请国内外从事上述研究并在近期取得突出研究成果的专家学者向大家分享他们最新研究成果。

Signal transduction is a fundamental process in nervous system and deficits in signal transduction pathways lead to many neural diseases. This forum invites some well-established scientists to share their research progresses in this field.

韩敬东 研究员，北京大学 
HAN Jackie, Peking University 

刘光慧 研究员，中国科学院动物研究所 
LIU Guang-Hui, Institute of Zoology, CAS 

人口老龄化加剧及衰老相关疾病高发是中国乃至世界面临的重大社会和科学问题。系统性组织器官的衰老以及衰老伴随的组织再生能力下降是导致机体衰老及相关疾病发生的重要原因。如何综合运用交叉学科手段解析组织器官衰老与再生的分子机制和调控通路，揭示其内在变化规律和作用网络，发掘可促进组织器官再生的新型分子靶标，针对性地发展高效安全的衰老干预策略，是衰老与再生领域的重要科学问题。本分会场将聚焦于"衰老与再生"这一主题，通过利用不同模式动物及衰老相关疾病模型及整合单细胞多组学、多维生命组学分析和大数据分析等前沿技术，阐明衰老与再生的分子机制，挖掘可干预衰老及衰老相关疾病或促进组织器官再生的潜在靶标，为实现健康老龄化提供科学依据和理论支持。

The increasing population aging and the high incidence of aging-related diseases are major social and scientific issues worldwide. The aging of tissues and organs in the whole body and the aging-related decline of tissue regeneration capacity are main factors leading to aging and aging-related diseases. It is of scientific importance to the field of aging and regeneration that we manage to use integrated methods to comprehensively dissect the regulatory pathways underlying aging and regeneration of tissues and organs, to reveal their molecular mechanisms, to discover new molecular targets that can promote tissue and organ regeneration, and to develop efficient and safe aging interventions. This session focuses on the topic of "aging and regeneration", involving studies using different model animals and aging-related disease models via the integrative analyses through single-cell multi-omics, multi-dimensional omics analysis and big data analysis and other cutting-edge technologies to dissect the molecular mechanisms of aging and regeneration and identify potential targets treating aging and aging-related diseases or promoting tissue and organ regeneration, thus providing scientific basis for achieving healthy aging.

宋保亮 院士、教授, 武汉大学 
SONG Bao-Liang, Wuhan University 

陈帅 教授，南京大学 
CHEN Shuai, Nanjing University 

糖脂代谢是生命活动的基础，为机体提供能量以及生物合成原料；其稳态在多层面受多重机制的网络化调控。遗传、饮食和环境等多种因素都可影响糖脂代谢，导致其稳态失衡，进而引发代谢疾病、心血管疾病、肿瘤等多种疾病。本分会场聚焦糖脂代谢调控机理及其稳态失衡引发疾病的病理机制，为相关研究领域科研工作者提供交流平台，旨在促进代谢研究领域发展。

Metabolism of glucose and lipids is a fundamental physiological process for life, not only providing energy for physical activities but also producing building blocks required for biosynthesis. Multiple mechanisms involving regulatory networks are required to maintain metabolic fitness, which can be deteriorated by genetic, dietary or environmental factors. The impairment of metabolic homeostasis may result in various diseases such as metabolic disorders, cardiovascular diseases and cancer. This section will focus on recent processes on the regulation of metabolic homeostasis and the pathological mechanisms in diseases related to metabolic abnormalities, and aim to exchange thoughts and to promote networking among participants.

赵忠 教授，中国科学技术大学
 ZHAO Zhong, University of Science and Technology of China 

焦雨铃 研究员，中国科学院遗传与发育生物学研究所 
Yuling Jiao, Institute of Genetics and Developmental Biology, CAS 

植物分生组织具有干细胞，并在胚后发育中维持着器官发生的能力。干细胞的维持和分化、器官发生过程的形态建成是植物发育过程的核心问题。本会场围绕本领域的新进展、新技术、交叉学科方法，来探讨植物干细胞命运决定和器官发生的机理。

Plant meristems harbor stem cells, and maintain organogenesis potential in post-embryonic development. Stem cell maintenance and differentiation, and organ initiation and morphogenesis are central to plant developmental biology. This session covers mechanisms underlying plant stem cell homeostasis and organogenesis, with focuses on new advances, new technologies, and interdisciplinary studies.

尹芝南 教授，暨南大学 
YIN Zhinan, Jinan University 

陈兰芬 教授，厦门大学
CHEN Lanfen, Xiamen University 

机体依赖神经系统与免疫系统感知外界刺激和内稳态失衡，引发多层次调控及适应性改变。本次会议将汇聚国内研究情感、行为、压力应激、神经损伤、免疫学的知名学者，围绕生理及病理状态下神经及免疫系统在局部及全身的交互调控机制开展深入交流，为心理障碍、免疫相关疾病的诊疗提供新的思路。

In response to the external stress and internal homeostasis imbalance, the body adapts to multi-level regulation and changes relying on the crosstalk of the nervous and immune systems. This conference will invite the researchers who interest in the study on the interaction between emotion, behavior, stress, nerve injury and immunology, and carry out in-depth communications on mutual regulation mechanism of nerve and immune system under physiological and pathological conditions. This conference will provide new ideas for the diagnosis and treatment of psychological disorders and immune-related diseases.

黄俊 教授，浙江大学生命科学研究院 
HUANG Jun, Life Sciences Institute, Zhejiang University 

许兴智 教授，深圳大学医学部 
Xingzhi (Xavier) Xu, Shenzhen University School of Medicine 

染色质复制包括DNA复制与染色质组装。目前关于真核DNA半保留复制机制的认识主要来自于对单细胞模式真核生物如酵母的研究，而对哺乳动物细胞DNA复制机制的认识方兴未艾。越来越多的证据提示染色质组装是由携带表观标记的亲本组蛋白（和非组蛋白）与新合成/募集的组蛋白（和非组蛋白）以接近于1:1的比例重建而成。染色质复制异常与重大疾病（如衰老和肿瘤）及罕见遗传病（如Meier-Gorlin综合征）的发生发展密切相关。本分会场将围绕染色质复制异常导致人类疾病发生发展机制，邀请全国知名专家学者进行交流研讨。

Chromatin replication involves both DNA replication and chromatin assembly. The current understanding of the mechanism of eukaryotic DNA semi-reserved replication mainly comes from the study of single-celled eukaryotic organisms such as yeast, while the understanding of the mechanism of DNA replication in mammalian cells is still emerging. Emerging evidences indicate that parental histones recycled from disassembled nucleosomes immediately ahead of the fork and newly synthesized naïve histones are mixed in a 1:1 ratio on newly replicated DNA. Deregulation of chromatin replication contributes to the initiation and progression of many human diseases such as cancers, aging and rare genetic disorders. In this session we invite outstanding experts and scholars for exchange and discussion focusing on chromatin replication and human diseases.

邹鹏 研究员，北京大学 
ZHOU Peng, Peking University 

刘行 教授, 中国科学技术大学 
LIU Xing, University of Science and Technology of China 

细胞可塑性是细胞响应内在节律和外源信号周而复始重塑其功能与结构的能力，是细胞生命活动的重要特征。化学生物学立足于发展具有化学特色的小分子探针等工具，为解析细胞可塑性活动中的生物大分子动态性与信号转导过程提供了重要技术。本分会场旨在交流细胞可塑性领域的化学生物学新技术和新成果，为在分子水平深入理解细胞可塑性的机理与靶向干预提供理论指导。

Cells are capable of dynamically and precisely altering their architect and function in response to environmental stimuli and internal clock, in a reversible process called cell plasticity. Through creating chemistry-enabled tools, chemical biology provides unique views into the signal transduction pathways and biological macromolecules that underlie cell plasticity. This session will highlight emerging techniques and new discoveries in the field of cell plasticity, with the aim of understanding the molecular mechanism and achieving spatiotemporal regulation of cell plasticity.

Miguel Esteban 研究员， 中国科学院广州生物医药与健康研究院 
Miguel Esteban, Guangzhou Institutes of Biomedicine and Health, CAS 

刘龙奇 研究员，深圳华大生命科学研究院 
LIU Longqi, BGI-Research 

空间转录组学能够保留组织空间位置信息，并同时解析组织切片转录组信息，能够应用于定义组织和生物体中基因原位表达信息。是近年复杂性系统研究的重要进展之一。本分会场将着重于空间转录组学的技术发展、前沿研究和算法。

Spatially resolved transcriptomic technologies are promising tools to study cell fate decisions in a physical microenvironment. This seminar session will focus on cutting-edge approaches, algorithms, and application to answer complex biological questions.

王光辉 教授，苏州大学 
WANG Guanghui, Soochow University 

张维绮 研究员，中国科学院北京基因组研究所（国家生物信息中心） 
ZHANG Weiqi, Beijing Institute of Genomics, China National Center for Bioinformation, CAS   

大脑是处理感觉信息和控制运动的器官，也执行多种高级功能，如语言、学习、思维和情绪。神经系统衰老引起神经功能改变和认知水平下降，并参与脑卒中、神经退行性疾病和痴呆等疾病的发生。尽管我们清楚地观察到衰老的脑改变，但参与这一过程的机制依然不明。本分会场聚焦衰老这一主题，探讨神经系统衰老与疾病，以及干预策略。

Brain is an organ that integrates sensory information and controls movement. It is also involved in intellectual functions, such as speech, learning, thought and emotion. Aging of the central nervous system leads to the decline of neuronal function and cognition, which is tightly associated with stroke, neurodegenerative diseases and dementia. Although the brain changes with aging is clear, the mechanism underlying aging process is still largely unknown. Our session focuses on the theme for aging in the central nervous system, exploring the mechanism of brain aging and the strategy of intervention.

周天华 教授，浙江大学 
ZHOU Tianhua, Zhejiang University  

林欣 教授，清华大学 
LIN Xin, Tsinghua University 

恶性肿瘤的遗传性、异质性以及动态演变过程已成为人类在恶性肿瘤治疗上的巨大挑战。以基因组信息为基础，结合蛋白质组、代谢组等相关内环境信息，为病人量身设计出最佳治疗方案，已成为肿瘤治疗的未来趋势所在，也在推动肿瘤精准诊疗的快速发展。基于大数据的精准医学为我们进一步探索肿瘤诊疗策略提供了巨大空间，需要生物学家、生物信息技术学家、医生等多方积极参与， 最终引领肿瘤医学进入一个全新的时代。

The heredity, heterogeneity, and dynamic progression of malignant tumors have been significant challenges for the treatment of malignant tumors. To overcome these challenges, integrating different omics, such as genomics, proteomics, and metabolomics, has been employed to be the best strategy to treat cancer patients. It, therefore, is becoming the trend of cancer treatment and promoting the rapid development of cancer precision medicine. By taking advantage of high throughput data, precision medicine will explore the opportunities to develop an effective cancer diagnosis and treatment strategy. Therefore, more experts in different backgrounds, such as biologists, bioinformatics scientists, and doctors, urgently need to work together to lead cancer research into a new era.

钟清 教授，上海交通大学 
ZHONG Qing, Shanghai Jiao Tong University 

莫玮 教授，厦门大学 
MO Wei, Xiamen University 

细胞死亡是细胞生命活动的终止。细胞死亡对机体发育和病理生理功能至关重要。本分会场将主要讨论新型细胞死亡方式对炎症以及相关疾病的影响及分子机制。

Cell death is the termination of vital activities. Cell death is crucial for animal development and pathophysiological functions. This session will mainly discuss different types of cell death pathways and their relationship to inflammation and human diseases, as well as underlying molecular mechanisms.

王佳伟 研究员, 中国科学院分子植物科学卓越创新中心 
WANG Jia-Wei, Center for Excellence in Molecular Plant Sciences, CAS 

严建兵 教授，华中农业大学 
YAN Jianbing, Huazhong Agricultural University 

最近两年植物单细胞测序技术的广泛应用为我们深入理解植物细胞异质性，干细胞分化轨迹，基因表达的动态性以及表观重置机理提供了有力的技术支撑。该分会场主题旨在邀请近两年在植物单细胞组学研究领域做出突出成绩的青年科研工作者进行报告，搭建一个工作交流和讨论平台，进一步提升国内植物单细胞测序技术的应用场景。

Recent technological advances have provided us unprecedented opportunities to analyze plant development and physiology at the single-cell level. High-throughput analyses of the genomes, epigenome and transcriptomes of single cells are providing novel and important insights into diverse processes such as cell differentiation, adaptation, gene-expression dynamics and epigenetic reprogramming. The theme of the session aims to invite young speakers with recent breakthroughs on the topics of plant single-cell omics study and provide a forum for open discussion among scientists working on related topics.

刘艳芬 研究员，上海科技大学 
LIU Yanfen, ShanghaiTech University 

王洪睿 教授，厦门大学 
WANG Hongrui, Xiamen University 

卢克锋 研究员，四川大学
LU Kefeng, Sichuan University 

蛋白质稳态的维持是细胞和机体赖以生存的基础。稳态的破坏会导致各类致病物质在体内的累积，从而引发多种疾病。近年来，基于细胞自噬和蛋白质泛素化调控的研究进展给相关疾病的治疗提供了多种潜在的解决方案。本分会场将着重探讨蛋白质质量控制机制和疾病领域的前沿进展及转化应用。

Cellular protein homeostasis is essential for cell viability and human health. Various diseases are associated with the disturbance of this balance. Autophagy and the ubiquitin-proteasome system play pivotal roles in the breakdown of intracellular unwanted materials and furthermore in the maintenance of protein homeostasis. In this session, our young scientists will share their recent breakthroughs on the topic of protein homeostasis and disease.