中国细胞生物学学会
2022年全国学术大会·厦门

于洪涛  YU Hongtao

讲习教授
Chair Professor

西湖大学
Westlake University

报告题目：

于洪涛教授1990年获北京大学学士学位， 1995年获美国哈佛大学博士学位，1995–1999年在美国哈佛大学医学院做博士后研究；1999–2019年历任美国得克萨斯大学西南医学中心药学系助理教授、副教授、教授、Serena S. Simmons讲席教授，2008–2019年兼任美国霍华德休斯研究所（HHMI）研究员。2019年，全职到西湖大学工作。于洪涛长期致力于细胞周期及基因组稳定性领域的研究，有效地结合细胞生物学，生物化学，遗传学，和生物物理学等多学科方法，对染色体分离和基因组稳定性在分子层面上的解析做出了重要贡献。曾获1999年Damon Runyon学者奖， 2000年Burroughs Wellcome药学新研究员奖， 2000年Packard科学工程奖学金， 2003年白血病及淋巴瘤学会学者奖，2003年 W. M. Keck杰出年轻学者奖。2012年，当选美国科学促进会会士。2018年，当选华裔生物学家学会董事会成员。

Dr. YU Hongtao is Chair Professor and Founding Dean of School of Life Sciences at Westlake University. Dr. Yu received his B.S. in Chemistry from Peking University in 1990, and received his Ph.D. in Chemistry from Harvard University in 1995. He then completed his postdoctoral training at Harvard Medical School. Dr. Yu began his independent research career in 1999 in Department of Pharmacology at University of Texas Southwestern Medical Center, and was promoted to Associate Professor with tenure in 2004 and to Professor in 2008. Dr. Yu is a recipient of the Damon Runyon Scholar Award (1999), Burroughs Wellcome New Investigator Award in Pharmacological Sciences (2000), Packard Fellowship for Science and Engineering (2000), Leukemia and Lymphoma Society Scholar Award (2003), and W. M. Keck Distinguished Young Scholar Award (2003). He was appointed Howard Hughes Medical Institute (HHMI) Investigator in 2008, and was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2012 and Board Member of Chinese Biological Investigator Society (CBIS) in 2018. He was the holder of the Serena S. Simmons Distinguished Chair in Cancer Immunopharmacology before joining the faculty of Westlake University in December, 2019.

Dr. Yu studies the cellular mechanisms that govern chromosome inheritance and integrity, focusing on understanding the spindle checkpoint and sister-chromatid cohesion—cellular systems and processes that ensure all chromosomes are properly segregated during cell division. Defects in these processes lead to genomic instability and aneuploidy, which can cause birth defects, premature aging, and tumorigenesis. Using a multidisciplinary approach, his laboratory has contributed significantly to the molecular understanding of chromosome segregation and genome maintenance. His research has highlighted a general principle in cell biology: exquisite spatiotemporal coordination of opposing activities and functionalities underlies cellular transitions.

代表性论文 / Representative publications in the last 5 years：

1. Lin, Z., Luo, X., and Yu, H. (2016) Structural basis of cohesin cleavage by separase. Nature 532, 131-134.
2. Choi, E., Zhang, X., Xing, C. and Yu, H. (2016) Mitotic checkpoint regulators control insulin signaling and metabolic homeostasis. Cell 166, 567-581.
3. Choi, E., Kikuchi, S., Gao, H., Brodzik, K., Nassour, I., Yopp, A., Singal, A. G., Zhu, H., and Yu, H. (2019) Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling. Nat. Commun. 10, 1473.
4. Kim, Y., Shi, Z., Zhang, H., Finkelstein, I. J.*, and Yu, H.* (2019) Human cohesin compacts DNA by loop extrusion. Science 366, 1345-1349 (*Corresponding authors).
5. Shi, Z., Gao, H., Bai, X.*, and Yu, H.* (2020) Cryo-EM structure of human cohesin-NIPBL-DNA complex. Science 368, 1454-1459 (*Corresponding authors).