季维智,男,1950年生,博士生导师,中国科学院院士,欧洲科学院院士。1978-1982年毕业于云南大学生物系;1983-2012年中科院昆明动物研究所研究员,其中1996-2005年任中科院昆明动物研究所第四任所长,2005-2008年任中科院昆明灵长类研究中心主任。现任昆明理工大学特聘教授,灵长类转化医学研究院院长,省部共建非人灵长类生物医学国家重点实验室主任、云南省灵长类生物医学动物重点实验室理事长。
季维智院士长期坚持灵长类生殖发育生物学的研究,围绕早期胚胎发育调控,干细胞多能性和人类疾病的猴模型及致病机理等科学问题,形成了从体外受精、胚胎早期发育、基因编辑以及干细胞等系统研究体系。率先在基因编辑灵长类动物模型取得重大突破,并获得了naïve猴多能性干细胞。实现了灵长类(人和猴)胚胎体外延长培养,解析了灵长类胚胎发育原肠发生与发育的重要事件,首次获得人猴嵌合胚胎。在胚胎发育和干细胞的基础理论、干细胞多能性和疾病研究都有重要意义。曾获“2015年中国细胞生物学学会终身贡献奖”、“2019年何梁何利基金科学与技术进步奖生命科学奖”。季维智院士长期为国家生殖发育、干细胞专家组服务,为中国生殖与干细胞研究作出了突出贡献,也为中国灵长类研究的国际化并跻身于世界先进行列发挥了重要作用。在 Cell, Science, Nature, Cell Stem Cell,PNAS等杂志以通讯作者或第一作者发表 SCI 论文 100 余篇。其中,2014 年在 Cell 发表的基因编辑猴的论文被评价为人类疾病模型建立的里程碑性工作、入选 2014 年世界十大科技进展(MIT Technology Review)、2014 年 Cell 最佳论文(Cell)、 2014 年世界最成功的 8 大事件之一(Nature)。
Member of Chinese Academy of Sciences (CAS)
State Key Laboratory of Primate Biomedical Research
Institute of Primate Translational Medicine
Kunming University of Science and Technology
Prof. JI Weizhi currently is a Member of Chinese Academy of Sciences (CAS), Professor and Director of the State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology. During the last three decades Prof. Ji has been devoted to developing non-human primate disease models and to advance regenerative and developmental biology with the overarching aim to improve human health. His research has focused on the mechanisms of early embryo development regulation, stem cell pluripotency and nonhuman primate models for human neurodevelopmental and neurodegenerative diseases. He has established a world leading primate research platform encompassing cutting edge biotechnology ranging from in vitro fertilization, early embryonic development, gene editing to stem cell lines which allows a unique approach. His lab developed the first gene-modified rhesus and cynomolgus monkeys via Cas9/RNA-mediated gene targeting in 2014, first proved the feasibility to generate chimeric monkeys using ESCs in 2015 and succeeded in extending in vitro culture for monkey in 2019 and for human early embryos in 2020. These gives a rare opportunity to study the developmental events of gastrulation in primates and offers insights into the new discoveries of fundamental theories in embryonic development, stem cells and promotes the development of innovative treatment for neurodevelopmental disorders. Prof. Ji has been providing his expertise in the national committees for reproduction and development biology, stem cells research and has led a series of state key research projects by the Ministry of Science and Technology, China. His research has been published in internationally recognized journals, including Cell, Science, Nature, Cell Stem Cell, PNAS and others, among which the study of the first primates born with genomes engineered by precision gene-targeting methods published in Cell has been regarded as a milestone of animal disease model development and listed as one of the 10 technology breakthrough in 2014 by MIT Technology Review, Best Research Article of 2014 by Cell, one of the 8 Success in science of 2014 by Nature.
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