中国细胞生物学学会
2022年全国学术大会·厦门

韩家淮  HAN Jiahuai

中国科学院院士，教授
Member of the Chinese Academy of Sciences(CAS), Professor
 
厦门大学
Xiamen University

报告题目：The factors that determine the outcomes of septic individuals

韩家淮教授，中国科学院院士，现任细胞应激生物学国家重点实验室（厦门大学）主任、厦门大学医学与生命科学学部主任、厦门大学医学院院长。1982年获北京大学学士学位，1985年获北京大学硕士学位，1990年获比利时布鲁塞尔自由大学分子生物学博士学位。

韩家淮院士是先天性免疫信号传导领域的世界知名学者，p38这一进化上保守的应激信号通道的发现者和权威，在细胞坏死的研究上也有引导性工作。迄今已在世界主流学术刊物上发表论文325篇，其中11篇发表在Cell、Nature、Science上（6篇为通讯作者）。论文被他人引用55000余次， H-index为115(Google Scholar)。因在信号传导研究的卓越贡献，获得长江学者成就奖、第六届谈家桢生命科学成就奖、国家自然科学二等奖等多种奖励。

Dr. HAN Jiahuai, an Elected Member of the Chinese Academy of Sciences, is the Director of the State Key Laboratory of Cellular Stress Biology (Xiamen University), Director of the Faculty of Medicine and Life Sciences and Dean of the School of Medicine of Xiamen University, China. Dr. HAN Jiahuai got his B.S. degree in Biochemistry in Beijing University (Peking University) in 1982, M.S. degree in Biochemistry in Beijing University (Peking University) in 1985 and Ph.D. degree in University of Brussels (University Libre de Bruxelles) in Protein Chemistry in 1990.

Dr. HAN Jiahuai is known for the discovery of the p38 signaling pathway, one of the most important pathways in intracellular signaling transduction. This pathway plays important roles in host defense, inflammation and stress responses. Another current focus of Han’s lab is molecular mechanisms of necroptosis and pyroptosis, two forms of inflammatory cell death. His laboratory is one of the three laboratories that discovered RIP3 as the key determinant of necroptosis and GSDMD as the executor of pyroptosis. Both of these works are milestone progress in the field of necroptosis and pyroptosis, respectively. The research in Han’s Lab contributed to our understanding of the molecular mechanisms of inflammation, cardiovascular disease and tumorigenesis, and thus could provide new ideas for the development of therapeutic intervention for these diseases. Till now, Dr. Han has published 325 papers in major academic journals including a number of publications in the most prestigious journals such as Science, Nature, Cell with an H-Index of 115(Google Scholar) and a total citation of 55,000.

代表性论文(2017-2021) / Representative papers:

1. Xiang Li, Chuan-Qi Zhong, Rui Wu, Xiaozheng Xu, Zhang-Hua Yang, Shaowei Cai, Xiurong Wu,Xin Chen, Zhiyong Yin, Qingzu He, Dianjie Li, Fei Xu, Yihua Yan, Hong Qi, Changchuan Xie,Jianwei Shuai*, Jiahuai Han*. RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes. Protein Cell. 2021 Jan 2. doi: 10.1007/s13238-020-00810-x.
2. Yang ZH#, Wu XN#, He P#, Wang X, Wu J, Ai T, Zhong CQ, Wu X, Cong Y, Zhu R, Li H, Cai ZY, Mo W*, Han J*. A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade. Mol Cell. 2020 Oct 15;80(2):296-310.
3. Wang Y, Fan X, Song Y, Liu Y, Liu R, Wu J, Li X, Yuan Q, Fu G, Xia N, Han J*. SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA. Cellular & Molecular Immunology. 2020, doi: 10.1038/s41423-020-0431-x.
4. Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P, X, Han J, Mo W. Gut Stem Cell Necroptosis by Genome Instability Triggers Bowel Inflammation. Nature. 2020 Apr; 580(7803): 386-390.
5. Zhong CQ, Wu R, Chen X, Wu S, Shuai J, Han J. Systematic assessment of the effect of internal library in targeted analysis of SWATH-MS. J Proteome Res. 2019 Oct 30. doi: 10.1021/acs.jproteome.9b00669.
6. Lu J, Shi W, Liang B, Chen C, Wu R, Lin H, Zhang Y, Han J. Efficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes. Cell Discov. 2019 Aug 6;5:39. doi: 10.1038/s41421-019-0108-8.
7. Ma H, Liu Z, Zhong CQ, Liu Y, Zhang Z, Liang Y, Li J, Han S, Han J. Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport. Mol Cell Biol. 2019 Apr 16; 39(9). pii: e00554-18. doi: 10.1128/MCB.00554-18..
8. Yang D, Liang Y, Zhao S, Ding Y, Zhuang Q, Shi Q, Ai T, Wu SQ, Han J. ZBP1 mediates interferon-induced necroptosis. Cell Mol Immunol. 2019 May 10. doi: 10.1038/s41423-019-0237-x.
9. Qiu X, Zhang Y, Han J. RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis. Cell Death Differ. 2018 May; 25(5): 821-824.
10. Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J. RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis. Nat Cell Biol. 2018 Feb; 20(2): 186-197.
11. Zhang Y, Chen X, Gueydan C, Han J. Plasma membrane changes during programmed cell deaths. Cell Res. 2018 Jan; 28(1): 9-21.
12. Ren J, Jia X, Zhao Y, Shi W, Lu J, Zhang Y, Wu J, Liang B, Wu R, Fu G, Han J. The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8+ T cells. Cell Mol Immunol. 2017 Jul; 14(7): 639-642.
13. Yang Z, Jiang B, Wang Y, Ni H, Zhang J, Xia J, Shi M, Hung LM, Ruan J, Mak TW, Li Q, Han J. 2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter. Cell Rep. 2017 May 30;19(9):1846-1857.
14. Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J. RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun. 2017 Feb 8; 8: 14329. doi: 10.1038/ncomms14329.
15. Huang D, Zheng X, Wang ZA, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J. MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process. Mol Cell Biol. 2017 Feb 15; 37(5). pii: e00497-16. doi: 10.1128/MCB.00497-16.