大会报告

Joseph S. Takahashi, Ph.D.
University of Texas Southwestern Medical Center, HHMI
报告题目:Molecular Architecture of the Circadian Clock in Mammals

Biography
Joseph Takahashi, Ph.D., is Chair of the Department of Neuroscience and an Investigator of the Howard Hughes Medical Institute at UT Southwestern. He currently holds the Loyd B. Sands Distinguished Chair in Neuroscience. Dr. Takahashi received a BA in biology from Swarthmore College in 1974 and a Ph.D. in neuroscience from the University of Oregon, Eugene, in 1981. For postdoctoral training, he was a pharmacology research associate at the National Institute of Mental Health from 1981–1983.
Dr. Takahashi has pioneered the use of forward genetics and positional cloning in the mouse as a tool for discovery of genes underlying neurobiology and behavior, and his discovery of the mouse and human clock genes led to a description of a conserved circadian clock mechanism in animals.

Publications

  1. Acosta-Rodríguez VA, de Groot MHM, Rijo-Ferreira F, Green CB, Takahashi JS. Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. Cell Metab. 2017 Jul 5;26(1):267-277.e2.
  2. He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH, Chen Z. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21.