大会报告

陈国强 院士,教授
上海交通大学医学院
报告题目:Nuclear PTEN safeguards pre-mRNA splicing to link Golgi extension and secretion for its tumor suppressive role

个人简介
陈国强,教授,上海交通大学医学院院长、上海交通大学副校长,细胞分化与凋亡教育部重点实验室主任,中国科学院院士,主要从事肿瘤尤其是白血病的病理生理学基础研究,在肿瘤细胞命运决定和肿瘤微环境调控机制方面获得系列创新性成果,在Cancer Cell, Nature Chem Biol, Nature Commun, Nature Cell Biol, J Clin Invest、JNCI, Blood, Leukemia、Oncogene等期刊上发表SCI论文160余篇, 被他引6000余次, 并先后作为第一完成人获国家自然科学二等奖、上海自然科学一等奖、中华医学科技一等奖等,并获何梁何利科学和技术进步奖、卫生部有突出贡献中青年专家、全国优秀博士学位论文指导教师、全国劳动模范等荣誉称号,并受邀担任国内外多个学术杂志的编委和悉尼大学、渥太华大学等荣誉教授。

代表性论文

  1. Gao YH, Wu ZX, Xie LQ, Li CX, Mao YQ, Duan YT, Han B, Han SF, Yu Y, Lu HJ, Yang PY, Xu TR, Xia JL, Chen GQ*, Wang LS*. VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2. Nat Commun. 2017, 8:15337
  2. Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, Shao H, Zeng H, Yu Z, Xie L, Xia F, Zhang F, Liu X, Zhang Y, Jiang H, Zhu J, Wan J, Wang C, Weng W, Xie J, Tao M, Zhang CC, Liu J, Chen GQ*, Zheng J*. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016, 126(12):4537-4553
  3. Shen SM, Guo M, Xiong Z, Yu Y, Zhao XY, Zhang FF, Chen GQ*. AIF inhibits tumor metastasis by protecting PTEN from oxidation. EMBO Rep. 2015 16(11):1563-80
  4. Li J, Xu Y, Long XD, Wang W, Jiao HK, Mei Z, Yin QQ, Ma LN, Zhou AW, Wang LS, Yao M, Xia Q, Chen GQ*. Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity. Cancer Cell. 2014, 25(1):118-31
  5. Duan CW, Shi J, Chen J, Wang B, Yu YH, Qin X, Zhou XC, Cai YJ, Li ZQ, Zhang F, Yin MZ, Tao Y, Mi JQ, Li LH, Enver T*, Chen GQ*, Hong DL*. Leukemia propagating cells rebuild an evolving niche in response to therapy. Cancer Cell. 2014, 25(6):778-793
  6. Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, Zhou AW, Wang LS, Sun HD, Chen GQ*. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol. 2012, 8(5):486-93