中国细胞生物学学会
2017年全国学术大会•厦门
2017年9月26-29日  中国 • 厦门国际会展中心
会议主题:探索细胞 创新未来
大会报告
  • 周琪
    院士,研究员
    中国科学院动物研究所
    报告题目:服务于医学转化的细胞模型与细胞治疗研究

个人简介
周琪,研究员,中国科学院大学副校长、动物研究所副所长、干细胞与生殖生物学国家重点实验室主任,中国科学院院士,主要从事干细胞与再生医学等研究工作。
在国际首次获得体细胞克隆大鼠、诱导多能干细胞来源的小鼠;建立了孤雌胚胎干细胞、单倍体胚胎干细胞等多种新型多能性干细胞系,获得单倍体胚胎干细胞来源的转基因小鼠和大鼠;首次创建了新型的异种杂合二倍体胚胎干细胞;利用经过基因组印记修饰的孤雌单倍体干细胞建立了“同性生殖”的新方法;发现可以判断干细胞多能性水平的分子标识并揭示其调控机制;建立了包括灵长类动物在内的多种人类疾病动物模型;合作在体外获得功能性精子等。推动建立了国际干细胞临床标准和临床级胚胎干细胞库;建立了多株临床级干细胞,开展了细胞治疗及药物筛选等临床前基础研究及安全性评估等工作。在干细胞领域已在Cell,Nature,Science等刊物发表SCI论文一百余篇。先后获得国家自然科学二等奖、TWAS生物学奖、周光召基金会青年创新奖、何梁何利基金科学与技术进步奖等多项奖励。

代表论文

  1. Li X#, Cui XL#, Wang JQ#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. (2016) Generation and application of mouse-rat allodiploid embryonic stem cells. Cell 164(1-2):279–292.
  2. Li Z#, Wan H#, Feng G#, Wang L#, He Z, Wang Y, Wang XJ, Li W*, Zhou Q*, Hu B*. (2016) Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res 26(1):135-138.
  3. Zhou Q#, Wang M#, Yuan Y#, Wang X, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng G, Shi Q, Zhao XY*, Sha J*, Zhou Q* (2016) Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. Cell Stem Cell 18(3):330-340.
  4. Chen Q#*, Yan M#, Cao Z#, Li X#, Zhang Y#, Shi J#, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E*, Zhai Q*, Zhou Q*. (2016) Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 351(6271):397-400.
  5. Wan H#, Feng C#, Teng F#, Yang S#, Hu B, Niu Y, Xiang AP, Fang W, Ji W, Li W*, Zhao X*, Zhou Q*. (2015) One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res 25(2):258-261.
  6. Chen Y#, Niu Y#, Li Y#, Ai Z, Kang Y, Shi H, Xiang Z, Yang Z, Tan T, Si W, Li W, Xia X, Zhou Q*, Ji W*, Li T*. (2015) Generation of cynomolgus monkey chimeric fetuses using embryonic stem cells. Cell Stem Cell 17(1):116-124.
  7. Chen T#, Hao YJ#, Zhang Y#, Li MM#, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ*, Yang YG*, Zhou Q*. (2015) m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 16(3):289-301.
  8. Li W#, Li X#, Li T#, Jiang MG#, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q*. (2014) Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell 14(3):404-414.
  9. Hai T#, Teng F#, Guo R, Li W, Zhou Q*. (2014) One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res 24(3):372-375.
  10. Li W#, Teng F#, Li T, Zhou Q*. (2013) Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat Biotechnol 31(8):684–686.
  11. Wan H#, He Z#, Dong M, Gu T, Luo GZ, Teng F, Xia B, Li W, Feng C, Li X, Li T, Shuai L, Fu R, Wang L, Wang XJ, Zhao XY*, Zhou Q*. (2013) Parthenogenetic haploid embryonic stem cells produce fertile mice. Cell Res 23(11):1330-1333.
  12. Li W#, Shuai L#, Wan H#, Dong M#, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. (2012) Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490(7420):407-411.
  13. Sheng C#, Zheng Q#, Wu J#, Xu Z, Wang L, Li W, Zhang H, Zhao XY, Liu L, Wang Z, Guo C, Wu HJ, Liu Z, Wang L, He S, Wang XJ, Chen Z*, Zhou Q*. (2012) Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res 22(1):208-218.
  14. Tong M#, Lv Z#, Liu L#, Zhu H#, Zheng QY#, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng F, Wang L, Wang XJ, Sha JH*, Zhou Q*. (2011) Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. Cell Res 21(11):1634-1637.
  15. Niu Y#, Yu Y#, Bernat A#, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P*, Zhang K*, Zhou Q*, Ji W*. (2010) Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. Proc Natl Acad Sci U S A 107(41):17663-17667.
  16. Liu L#, Luo GZ#, Yang W#, Zhao X#, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ*, Zhou Q*. (2010) Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J Biol Chem 285(25):19483-19490.
  17. Zhao XY#, Li W#, Lv Z#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F*, Zhou Q*. (2009) iPS cells produce viable mice through tetraploid complementation. Nature 461(7260):86-90.
  18. Mai Q#, Yu Y#, Li T, Wang L, Chen MJ, Huang SZ*, Zhou C*, Zhou Q*. (2007) Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. Cell Res 17(12):1008-1019.
  19. Zhou Q#*, Yang SH#, Ding CH#, He XC, Xie YH, Hildebrandt TB, Mitalipov SM, Tang XH, Wolf DP*, Ji WZ*. (2006) A comparative approach to somatic cell nuclear transfer in the rhesus monkey. Hum Reproduc 21(10):2564-2571.
  20. Zhou Q, Renard JP*, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J. (2003) Generation of fertile cloned rats by regulating oocyte activation. Science 302(5648):1179.