中国细胞生物学学会
2017年全国学术大会•厦门
2017年9月26-29日  中国 • 厦门国际会展中心
会议主题:探索细胞 创新未来
大会报告
  • 潘多加
    教授
    德克萨斯大学西南医学中心
    报告题目:Hippo signaling in growth control and beyond

Current Appointments
Investigator, Howard Hughes Medical Institute
Bashour Distinguished Professor and Chairman, Department of Physiology
University of Texas Southwestern Medical Center
Dallas, TX75390-9040
Telephone: 214-645-8065(office)
E-mail: duojia.pan@utsouthwestern.edu

Education and Training
1984-1988: B.S. Biochemistry, Peking University
1988-1989: China-United States Biochemistry Examination and Application (CUSBEA)Program
1989-1993: Ph.D. in Biological Chemistry, UCLA School of Medicine (advisor: Albert Courey)
1993-1998: Postdoctoral Fellowship, UC Berkeley (advisor: Gerald Rubin)

Professional Experience
1998-2004: Assistant Professor of Physiology, UT Southwestern Medical Center
2004-2004: Associate Professor of Physiology, UT Southwestern MedicalCenter
2004-2009: Associate Professor of Molecular Biology & Genetics, JohnsHopkinsUniversitySchool of Medicine
2008-present: Investigator, Howard Hughes Medical Institute
2009-2016: Professor of Molecular Biology & Genetics, Johns Hopkins University School of Medicine
2016-present: Professor and Chairman, Department of Physiology, UT Southwestern Medical Center

Professional memberships
Genetics Society of America
American Association for the Advancement of Science

Awards and Recognition
1988-1989: China-United States Biochemistry Examination and Application (CUSBEA) Scholarship
1993-1996: Postdoctoral Fellowship of the Jane Coffin Childs Memorial Fund for Medical Research
1998-2004: Endowed Scholars in Medical Science, UT Southwestern
2001-2005: American Heart Association National Scientist Development Award
2003-2006: American Cancer Society Research Scholar
2006-2008: Leukemia & Lymphoma Society Scholar
2012: Fellow, American Association for the Advancement of Science
2013: Paul Marks Prize for Cancer Research
2016-present: The Fouad A. and Val ImmBashour Distinguished Chair in Physiology

Representative Publications

  1. Wu, S., Huang, J., Dong, J., and Pan, D.  (2003) hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and wartsCell 114, 445-456. PMID: 12941273.
  2. Huang, J., Wu, S., Barrera, J., Matthews, K., and Pan, D. (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homologue of YAP. Cell 122, 421-434. PMID: 16096061.
  3. Dong, J., Feldman, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., and Pan, D. (2007) Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130: 1120-1133. PMID: 2666353.
  4. Wu, S., Liu, Y., Zheng, Y., Dong, J., and Pan, D. (2008) The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev. Cell, 14: 388-98. PMID: 18258486.
  5. Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W-M., and Pan, D. (2010) Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev. Cell, 18: 288-299. PMID: 2858562.
  6. Zhang, N., Bai, H., David, K.K., Dong, J., Zheng Y., Cai, J., Giovannini, M., Liu, P., Anders, A.A., and Pan, D. (2010) The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev. Cell, 19: 27-38. PMID: 2925178.
  7. Koontz, L.M., Liu-Chttenden, Y., Yin, F., Zheng, Y., Yu, J., Huang, B., Chen, Q., Wu, S., and Pan, D. (2013) The Hippo effector Yorkie controls normal tissue growth by antagonizing Scalloped-mediated default repression. Dev. Cell, 25: 388-401. PMID: 3705890.
  8. Yin, F., Yu, J., Zheng, Y., Chen, Q., Zhang, N., and Pan, D. (2013) Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell, 154: 1342-1355. PMID: 3835333.
  9. Zheng, Y., Wang, W., Liu, B., Deng, H., Uster, E., and Pan, D. (2015) Identification of Happyhour/MAP4K as alternative Hpo/Mst-like kinases in the Hippo kinase cascade. Dev. Cell, 34: 642-655. PMID: 26364751.
  10. Liu, B., Zheng, Y., Yin, F., Yu, J., Silverman, N., and Pan, D. (2016) Toll receptor-mediated Hippo signaling controls innate immunity in Drosophila. Cell, 164: 406-419. PMID: 26824654.