中国细胞生物学学会
2017年全国学术大会•厦门
2017年9月26-29日  中国 • 厦门国际会展中心
会议主题:探索细胞 创新未来
大会报告
  • 林圣彩
    教授
    厦门大学生命科学学院
    报告题目:AMPK的激活机制:葡萄糖的感应通路及其生理意义

EDUCATION
1980 - 1984: B.S., Biology, Xiamen (Amoy) University
1984 - 1985: English Language, Zhongshan University
1985 - 1991: Ph.D., Biochemistry, University of Texas Southwestern Medical Center at Dallas (Mentor: Marcelle Morrison-Bogorad)

EMPLOYMENT EXPERIENCE
1991 - 1995: Associate, Howard Hughes Medical Institute, University of California, San Diego (Mentor: M Geoff Rosenfeld)
1995 - 2001: Senior Scientist (Assistant Professor), Institute of Molecular and Cell Biology (IMCB), National University of Singapore
2001 - 2004: Assistant Professor, Department of Biochemistry, Hong Kong University of Science & Technology
2004 - 2006: Associate Professor (with tenure), Department of Biochemistry, Hong Kong University of Science & Technology
2001 - present: Professor, School of Life Sciences, Xiamen University
2001 - Present: Cheung Kong Scholar, School of Life Sciences, Xiamen University
2003 - present: Dean, School of Life Sciences, Xiamen University

HONORS AND AWARDS
CUSBEA Studentship (China-US Biochemistry and Molecular Biology Examination and Application Program) and CUSBEA Scholarship (1985)
Awarded the NARSAD Young Investigator Award, 1995
Co-organiser, Gordon Research Conference: Mechanisms of Cell Signaling, Singapore, 1999
Organizer, Wnt Meeting, 2009
National Outstanding Young Investigator Award, China (2001)
Cheung Kong Scholar (2002)
Chief Scientist, Grant consortium on metabolic homeostasis, Chinese Ministry of Science and Technology (2011)
Top 10 Sciences of China for the Year of 2012
Editorial Board Member, JBC, starting from July 2013
Award of Scientific Achievement of Fujian Province, 2014
Bao-gang Outstanding Teaching Award, 2014
Vice President of Chinese Society of Biochemistry and Molecular Biology, since 2014
Co-Chair, International Meeting on AMPK, 2016
Deputy Chair, Biochemical Journal (UK), since 2016
Editorial Board, Signal Transduction and Targeted Therapy, since 2016
Co-organizer, Cold Spring Harbor Symposium Asia: Cancer and Metabolism (2016)

代表论文

  1. Li, Q., Lin, S.Y., Wang, X., Lian, G., Lu. Z., Guo, H., Ruan, K., Wang, Y., Ye, Z., Han, J., and Lin, S-C*. Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat Cell Biol, 11, 1128-1135, 2009.
  2. Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y,  Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, and Lin SC*. GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science, 336, 477, 2012
  3. Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC*. The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation. Cell Res, 22: 1246-57, 2012
  4. Li TY, Lin SY, Lin SC*. Mechanism and Physiological Significance of Growth Factor Related Autophagy. Physiology, 28, 423-431, 2013
  5. Zhang YL, Guo HL, Zhang CS, Lin SY, Li P, WU JW, and Lin SC*. AMP as a low energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism, 18, 546–555, 2013
  6. Zhang CS, Jiang B,Li MQ, Zhu MJ, Peng YY, Zhang YL, Wu YQ, Li TY, Liang Y, Lu ZL, Lian GL, Liu Q, Guo HL,Yin ZY, Ye ZY, Han J, Wu JW, Yin HY, Lin SY, Lin SC*. The Lysosomal v-ATPase-Ragulator Complex is a Common Activator for AMPK and mTORC1, acting as a Switch between Catabolism and Anabolism. Cell Metab, 20, 526-40, 2014
  7. Zhang CS, Liu Q, Li MQ, Lin SY, Peng YY, Wu D, Li TY, Fu Q, Jia WP, Wang XJ, Ma T, Zong Y, Cui JW, Pu CF, Lian GL, Guo GL, Ye ZY, Lin SC*. RHOBTB3 promotes proteasomal degradation of HIF1alpha through facilitating hydroxylation and suppresses the Warburg effect. Cell Res, 25, 1025-42, 2015
  8. Zhang CS, and Lin SC*. AMPK Promotes Mitophagy through Facilitating Mitochondrial Fission. Cell Metab, 23, 399-341, 2016
  9. Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, Zhang X, Li X, Chen T, Huang HY, He X, Wang Y, Wu YQ, Chen S, Jiang M, Chen C, Xie C, Yang JY, Lin Y, Zhao S, Ye Z, Lin SY, Chiu DT, Lin SC. ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in addition to Autophagy. Mol Cell, 62, 359-370, 2016
  10. Zhang CS, Li M, Ma T, Zong Y, Cui J, Feng JW, Wu, YQ, Lin SY, and Lin SC*. Metformin activates AMPK through the lysosomal pathway. Cell Metab, in press